Reexamination of accepted techniques of histamine therapy for episodic vertigos in the light of clinical experience and recent laboratory studies suggests than an optimum dosage of exogenous histamine may be of therapeutic value in selected cases.
Patients surmised to be capable of manifesting an abnormal response to stress by local microcirculatory dysfunction are, theoretically, favorable candidates for such therapy. Microvascular dysfunction of the cochlear or vestibular labyrinth may or may not contraindicate intravenous histamine therapy.
Wilson WH. Intravenous and Optimum-Dosage Histamine Therapy in Meniere's Disease. Arch Otolaryngol. 1973;97(2):139–141. doi:10.1001/archotol.1973.00780010145009
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