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February 1973

Intravenous and Optimum-Dosage Histamine Therapy in Meniere's Disease

Author Affiliations

From the Presbyterian Medical Center, Denver.

Arch Otolaryngol. 1973;97(2):139-141. doi:10.1001/archotol.1973.00780010145009

Reexamination of accepted techniques of histamine therapy for episodic vertigos in the light of clinical experience and recent laboratory studies suggests than an optimum dosage of exogenous histamine may be of therapeutic value in selected cases.

Patients surmised to be capable of manifesting an abnormal response to stress by local microcirculatory dysfunction are, theoretically, favorable candidates for such therapy. Microvascular dysfunction of the cochlear or vestibular labyrinth may or may not contraindicate intravenous histamine therapy.