Mechanical depletion of circulating lymphocytes is an effective and safe means of immunosuppression which could have clinical application in laryngeal homotransplantation. A new method of internal thoracic duct-esophageal shunt which effectively depresses peripheral lymphocyte counts to less than 10% for prolonged periods has recently been reported by Harvey et al (Laryngoscope 81:1126, 1971). The advantage of this technique is that all cellular elements in thoracic duct lymph are destroyed in the stomach without concomitant loss of important serum proteins and electrolytes.
This experiment studies the effectiveness of chronic mechanical lymphocyte depletion by the above method on the survival time of skin homografts in mongrel dogs.
Flintoff WM, Tucker HM. Increased Homograft Survival: Internal Thoracic Duct-Esophageal Shunt. Arch Otolaryngol. 1973;97(3):251–252. doi:10.1001/archotol.1973.00780010259005
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