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Article
March 1973

ETHACRYNIC ACID-Reply

Author Affiliations

Department of Surgery The University of North Carolina at Chapel Hill The School of Medicine Division of Otolaryngology

Arch Otolaryngol. 1973;97(3):300. doi:10.1001/archotol.1973.00780010308021

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Abstract

Reply

We are very grateful to Dr. Cohn for his comments on our article. According to Cohn et al (Science 171: 910, 1971) and Brusilow (Fed Proc 31: 298, 1972) low doses (1 to 5 mg/kg) of ethacrynic acid produce an increase of Na+ concentration and a drop of K+ concentration inside the cochlear duct in dogs; however, Silverstein and Yules (Laryngoscope 81:873-888, 1971), after 30 mg/kg of ethacrynic acid, described an increase of Na+ concentration and no change of K+ concentration inside the cochlear duct in cats. Wilson and Juhn (Fed Proc 29:805, 1970) reported an increase in the concentration of K+ in perilymph from guinea pigs after very large doses of ethacrynic acid. Recently, we have found that after local application of 1 × 10−3M solution of ethacrynic acid into the scala tympani, there were no significant changes of K+ concentration inside the cochlear duct. Our results

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