A pediatric formulation of clindamycin was evaluated in comparison to ampicillin sodium in treatment of otitis media. Ampicillin and clindamycin were provided in identical numbered bottles and dispensed to 271 children.
The randomization procedures employed for assignment of therapeutic regimen yielded two groups which were remarkably similar in relation to age, sex, and clinical severity of disease. No significant differences in clinical response to therapy were observed even when data were evaluated with regard to specific organisms isolated. Clindamycin proved to be effective therapy for otitis media due to penicillin-sensitive and penicillin-resistant Staphylococcus aureus, epidermidis, and Diplococcus pneumoniae. Differences between the two regimens in the response of otitis media caused by Hemophilus influenzae were noted. We would not recommend clindamycin for routine treatment of otitis media caused by H influenzae.
Feigin RD, Keeney RE, Nusrala J, Shackelford PG, Lins RD. Efficacy of Clindamycin Therapy for Otitis Media. Arch Otolaryngol. 1973;98(1):27–31. doi:10.1001/archotol.1973.00780020031008
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