A case of neurofibroma of the larynx occurring with generalized neurofibromatosis (Von Recklinghausen disease) is reported and the literature reviewed. Typical signs include those of the generalized disease (cutaneous and visceral neurofibromas, café-au-lait spots, bony abnormalities, and mental deficiency) together with the symptoms of a slowly growing laryngeal mass, eg, dyspnea, hoarseness, and dysphagia.
The diagnosis is confirmed by direct laryngoscopy and biopsy. Small, encapsulated tumors may be completely excised at laryngoscopy, whereas larger, less well-encapsulated ones may require lateral thyrotomy or laryngofissure for complete removal.
Jafek BW, Stern FA. Neurofibroma of the Larynx Occurring With Von Recklinghausen Disease: Report of a Case. Arch Otolaryngol. 1973;98(2):77–79. doi:10.1001/archotol.1973.00780020083002
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