A 20-year-old man with long-standing laryngotracheobronchial papillomatosis underwent laryngectomy because of extensive, persistent disease that had left him a useless larynx, was repeatedly infiltrating the tracheostomy, and was extending into the prelaryngeal soft tissues.
The laryngectomy specimen was studied by whole-organ sections, which disclosed that the infiltrative component was identical to the papillomas that obliterated the glottis and partly filled the trachea. There was no cytologic evidence of malignancy. The term "invasive laryngeal papillomatosis" is suggested. On occasion, laryngectomy may be required to remove extensive papillomatous disease in the absence of carcinoma.
Robert E. Fechner, Helmuth Goepfert, Bobby R. Alford. Invasive Laryngeal Papillomatosis. Arch Otolaryngol. 1974;99(2):147–151. doi:10.1001/archotol.1974.00780030153018