In experimental animals, tobramycin, an aminoglycoside antibiotic, has been shown to have ototoxic properties when administered in concentrations above 100 mg/kg, as measured by changes in electrophysiologic potentials. The ototoxic properties are related both to concentration of the drug and the time interval of exposure.
It has been shown that the drug has stronger and probably primary effects in the organ of Corti. Changes in the stria vascularis occur only in very high doses. Concomitant renal toxicity has been demonstrated previously in experiments. The renal function should be evaluated prior to administration of the drug. In addition, constant monitoring of renal function should be employed during its administration. Increased blood levels may occur with impaired renal function, leading to additional ototoxic effects.
Logan TB, Prazma J, Thomas WG, Fischer ND. Tobramycin Ototoxicity. Arch Otolaryngol. 1974;99(3):190–193. doi:10.1001/archotol.1974.00780030198008
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