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May 1974

Laser Irradiation of the Stria Vascularis

Author Affiliations

Uppsala, Sweden
From the departments of otolaryngology and physics, University of Uppsala, Uppsala, Sweden, and the Research Institute of National Defense, Stockholm, Sweden. Dr. Sugar was a visiting research fellow, University of Illinois, College of Medicine, 1971 to 1972, and is now with Northwestern University, Department of Surgery, Chicago.

Arch Otolaryngol. 1974;99(5):330-336. doi:10.1001/archotol.1974.00780030342004

The cochleas of 24 surviving guinea pigs were exposed to continuous-wave argon laser irradiation for periods of one half to three seconds at power densities between 1 and 2 kw/sq cm. The stria vascularis was stained by the peroxidase-benzidine method and studied by light microscopy in acute and long-term animals. Well-defined and reproducible lesions with a width of 50μm to 300μm were observed. The acute changes consisted of central coagulation necrosis as well as surrounding zones of reversible and irreversible damage. The long-term animals showed capillary fibrous strands adjacent to an area of completely destroyed, unregenerated stria vascularis.