Sodium iodine I 131 has been used widely in the diagnosis and treatment of various thyroid disorders. It has been implicated in several cases of infant thyroid hypoplasia when given in thyroid-ablative doses to pregnant women during the third or fourth month of pregnancy. A hypothyroid infant was born to a mother who had received 50 microcuries of sodium iodide I 131 at 13½ weeks' gestation. The resultant tracheal hypoplasia in the region of the thyroid gland with stridor and mild respiratory obstruction represents a previously unreported addition to the syndrome and is believed to be the result of radioactive nuclide uptake by the fetal thyroid. Classic cretinoid features were not present in the infant.
Jafek BW, Small R, Lillian DL. Congenital Radioactive Iodine— Induced Stridor and Hypothyroidism. Arch Otolaryngol. 1974;99(5):369–371. doi:10.1001/archotol.1974.00780030381010
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