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May 1974

Sodium Salicylate

Author Affiliations

Biophysics and Instrumentation Section Research Services Branch Research Triangle Park, NC 27709

Arch Otolaryngol. 1974;99(5):393. doi:10.1001/archotol.1974.00780030405019

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To the Editor.—I read with interest the article by Mitchell et al, "Electrophysiological Study of the Effect of Sodium Salicylate Upon the Cochlea" in the November 1973 issue of the Archives (98:297) that showed that a single subcutaneous dose of sodium salicylate interferes with the cochlea's ability to generate a nerveevoked potential (N,) without a simultaneous change in the cochlea's ability to generate the alternating current cochlear potential. Recent work in my laboratory has a bearing on this study and may be of interest to readers concerned with the pathogenesis of salicylate ototoxicity.

Under the hypothesis that the toxic action of salicylates occurs in the spiral ganglion and auditory nerve, an ultrastructural study of these tissues was performed in salicylate-treated animals. Six young adult albino guinea pigs received daily subcutaneous doses of 200 mg sodium salicylate per kilogram of body weight for five days from a saline solution of

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