Nine cases of nasal septal perforation occurred due to systemic lupus erythematosus (SLE). This complication is most likely to occur during an exacerbation of the disease some months or years after the diagnosis of SLE has been established. Epistaxis is a constant initial symptom. Such perforations tend to persist, gradually enlarge, and become symptomatic during subsequent exacerbations of the underlying disease. Conservative treatment is indicated.
Snyder GG, McCarthy RE, Toomey JM, Rothfield NF. Nasal Septal Perforation in Systemic Lupus Erythematosus. Arch Otolaryngol. 1974;99(6):456–457. doi:10.1001/archotol.1974.00780030470016
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