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September 1974

Pseudomembranous Colitis After The Prophylactic Use of Clindamycin

Arch Otolaryngol. 1974;100(3):246. doi:10.1001/archotol.1974.00780040254024

To the Editor.—Clindamycin has become a popular antibiotic choice following a number of head and neck surgical procedures. Clindamycin is a semisynthetic, wide-spectrum antibiotic derived from the parent compound, lincomycin and was introduced because it had far fewer gastrointestinal side effects than lincomycin.1

A number of documented hospitalized cases of pseudomembranous colitis associated with oral clindamycin administration have been noted in the literature.2-4 Pseudomembranous colitis can be a very severe disorder associated with prolonged disabling diarrhea, abdominal pain and cramps, fever, and occasional hematochezia. Friable, edematous mucosa with un

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