Thirty-four patients with Meniere disease were treated with chlorthalidone (Hygroton) and observed for seven years. Twenty-six patients displayed drug-related improvements, primarily a reduction of the prevalence and intensity of vertigo. In four patients the effect was minor. Four patients appeared to be totally chlorthalidone-resistant, in spite of positive glycerin tests, and two of them needed operation.
Chlorthalidone was also given to 220 severely incapacitated patients who were hospitalized for further examination and eventual operation. Improvements were obtained so that operation was avoided in 133 patients (60%).
Periodic or long-term treatment with chlorthalidone produces a considerable symptomatic relief in many patients during the active stage of the disease. It reduces the need for surgical intervention and helps the patient retain an active life, but does not arrest the degenerative course of the disease.
Klockhoff I, Lindblom U, Stahle J. Diuretic Treatment of Meniere Disease: Long-Term Results With Chlorthalidone. Arch Otolaryngol. 1974;100(4):262–265. doi:10.1001/archotol.1974.00780040272004
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