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November 1974

Nasal Cryptococcosis

Author Affiliations

From the departments of otolaryngology and maxillofacial surgery (Dr. Briggs) and pathology (Drs. Barney and Bahu), Northwestern University McGaw Medical Center, Chicago.

Arch Otolaryngol. 1974;100(5):390-392. doi:10.1001/archotol.1974.00780040402018

An unusual case of cryptococcosis occurred as an ulcerating mass in the nasal vestibule, with subsequent development of meningoencephalitis. This disease usually occurs with neurological or pulmonary symptoms and rarely as an otolaryngologic disease. Biopsy of the nasal mass with special histochemical stains and india ink preparations confirmed the diagnosis.

Treatment with amphotericin B and flucytosine was monitored using specific slide latex agglutination tests. Complete resolution of the disease in this patient supports the use of flucytosine in treating Cryptococcus neoformans infections.