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January 1975

Benign Lymphoepithelial Lesions of the Salivary Glands

Author Affiliations

From the Department of Otolaryngology, College of Medicine, the Ohio State University, Columbus.

Arch Otolaryngol. 1975;101(1):71-75. doi:10.1001/archotol.1975.00780300075020

The benign lymphoepithelial lesion of the salivary glands has been labeled with multiple, confusing terms. We recommend the abandonment of the vague term of Mikulicz disease.

The histopathologic findings of lymphoid infiltration, intraductal proliferation, epimyoepithelial islands, and acinar atrophy are presented. The relationship between this lesion and autoimmune diseases, including Sjögren syndrome, is noted. Difficulty of histopathologic differentiation between this lesion and malignant lymphoma can occur. The association of the benign lymphoepithelial lesion with the simultaneous presence or future development of lymphoma is discussed.