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February 1975

Inhalation Anesthesia for the Short-Term Guinea Pig Experiment

Author Affiliations

From the Department of Otolaryngology, University of Washington, Seattle.

Arch Otolaryngol. 1975;101(2):138-139. doi:10.1001/archotol.1975.00780310060016

The cochlear potentials, as a measure of auditory function, are an area of growing interest in otolaryngology. Much of this work is being performed in guinea pig experiments. If good cochlear electrophysiological data are to be obtained from such experiments, predictable anesthesia is also required. Achieving a stable level of general anesthesia in the guinea pig is commonly known to be difficult. Intraperitoneal anesthesic agents such as pentobarbital (Nembutal) and urethan (Urethane) are routinely used in most short-term electrophysiological studies with the guinea pig. It is not only difficult using such agents to achieve good surgical anesthesia, but they also have a substantial mortality,1 which is a waste of animals and research time. Furthermore, there is a wide spectrum of responses from animal to animal with a given intraperitoneal anesthetic agent and dose per body weight. These situations tend to cause the electrophysiological state of the experimental preparation to become