Using 15 fresh guinea pig temporal bones, Eustachian tubal function was tested repeatedly before and after saline washing to demonstrate the effect of surface-active agent. Although tubal opening pressures for the 15 ears varied considerably, in each ear tested, a higher pressure was required to open the Eustachian tube after saline washing (P <.001).
A significant statistical difference in Eustachian tube opening pressure was also found between consecutive trials before washing the Eustachian tube with saline (P <.001). This phenomenon disappeared after saline washing. It is possible that these phenomena occurred as a result of surface-active agent (surfactant) functioning in the Eustachian tube.
Rapport PN, Lim DJ, Weiss HS. Surface-Active Agent in Eustachian Tube Function. Arch Otolaryngol. 1975;101(5):305–311. doi:10.1001/archotol.1975.00780340037008
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