• A group of patients with a history of recurrent tonsillitis were observed during an acute episode to determine the cause of the infection.
The microbial pathogen that was consistently implicated was the Epstein-Barr virus. Seventeen (65%) of 26 patients exhibited a substantial seroconversion to the early antigen of Epstein-Barr-virus-infected lymphoblastoid cells (P3HR-1).
We conclude that there is a high incidence of tonsillitis associated with the Epstein-Barr virus. The propensity of the virus for the palatine tonsils, a rich source of B cells, is suggested. Furthermore, the value of monitoring early antigen titers to confirm the nature of the infection is apparent, bearing relevance to future studies of this virus.
(Arch Otolaryngol 101:552-556, 1975)
Veltri RW, Sprinkle PM, McClung JE. Epstein-Barr Virus Associated With Episodes of Recurrent Tonsillitis. Arch Otolaryngol. 1975;101(9):552–556. doi:10.1001/archotol.1975.00780380030007
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