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September 1975

Myasthenia Gravis Focal to the Larynx: Report of a Case

Author Affiliations

From the departments of neurology (Dr. Neiman) and otolaryngology (Dr. Mountjoy), University Hospitals, and the Department of Speech and Hearing, Wendell Johnson Speech and Hearing Center (Dr. Allen), Iowa City. Dr. Neiman is now with the Lexington Clinic, Lexington, Ky.

Arch Otolaryngol. 1975;101(9):569-570. doi:10.1001/archotol.1975.00780380047012

• Myasthenia gravis, focal to the larynx, should be considered in the differential diagnosis of intermittent breathy dysphonia and aphonia. A 20-year-old woman had intermittent breathy dysphonia and aphonia as the sole manifestation of myasthenia gravis. The vocal cords were flaccid, and adducted to the paramedian position for phonation. Improvement of laryngeal function was demonstrated with edrophonium and neostigmine bromide. Therapy with pyridostigmine bromide (Mestinon) maintained normal phonation.

(Arch Otolaryngol 101:569-570, 1975)