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September 1975

Temporal Bone Findings in Cryptococcal Meningitis

Author Affiliations

From the Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine and the Methodist Hospital, Houston.

Arch Otolaryngol. 1975;101(9):577-583. doi:10.1001/archotol.1975.00780380055015

• A 19-year-old woman with cryptococcal meningitis died as a result of her disease, in spite of both intravenous and intraventricular administration of amphotericin B. Gross and microscopic examinations revealed multiple cysts containing Cryptococcus neoformans within the central nervous system. Studies of the temporal bones revealed both neural and end organ destruction with the presence of Cryptococcus when stained by Gomori methenamine silver nitrate method. We present the results of audiometric and vestibular examinations. The case history depicts a progressive neurological involvement by Cryptococcus.

(Arch Otolaryngol 101:577-583, 1975)