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November 1975

Transfer Factor: Potential for Therapy of Malignant Diseases

Author Affiliations

From the Division of Hematology and Oncology, Ohio State University College of Medicine, Columbus.

Arch Otolaryngol. 1975;101(11):664-666. doi:10.1001/archotol.1975.00780400022006

• Transfer factor (TF) is a low molecular weight nonantigenic extract of leukocytes that is capable of transferring cell-mediated immunity from an immune individual to a nonimmune individual. Reports of efficacy of transfer factor in immunodeficiency states and chronic infectious diseases, as well as its lack of toxicity, have spurred clinical trials of TF therapy in human malignant diseases. Variables such as donor and patient selection, dose of TF, and use of concurrent therapy have not been explored. Preliminary reports suggest that TF may find a role as adjuvant therapy in human malignant neoplasms.

(Arch Otolaryngol 101:664-666, 1975)