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July 1976

Viral Infection as a Cause of Acute Peripheral Facial Palsy

Author Affiliations

From the departments of otolaryngology (Drs Djupesland, Berdal, and Johannessen), bacteriology (Dr Degré), neurology (Dr Stien), and clinical chemistry (Dr Skrede), Rikshospitalet, National Hospital of Norway, University Hospital, Oslo.

Arch Otolaryngol. 1976;102(7):403-406. doi:10.1001/archotol.1976.00780120051005

• Among 51 patients with acute peripheral facial palsy, varicella-zoster virus was isolated from the cerebrospinal fluid (CSF) in one case, and Herpesvirus hominis from the nasopharynx in two cases.

In 12 other cases, complement-fixing antibody or hemagglutination inhibition tests indicated a recent viral infection (varicella-zoster, seven; herpes simplex, one; cytomegalovirus, one; influenza type B virus, two; and mumps virus, one). One additional patient had clinical signs of herpes zoster oticus.

About one third of these 16 virus-positive patients, but also one third of the remaining group, had increased levels of α1-antitrypsin, orosomucoid, haptoglobin, and immunoglobulins. Evidently, an inflammatory reaction preceded or coincided with the facial palsy in both groups. In CSF, an increase of total proteins and γ-globulins was frequently found among all 20 patients examined (eight were viruspositive).

(Arch Otolaryngol 102:403-406, 1976)

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