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October 1976

Ultrastructure of the Stroma of Nasal Polyps: Cilia in Stromal Fibroblasts

Author Affiliations

From the Department of Pathology, University of Glasgow, Western Infirmary, Glasgow, Scotland.

Arch Otolaryngol. 1976;102(10):589-595. doi:10.1001/archotol.1976.00780150057002

• Ultrastructural examination of the stroma of simple nasal polyps has shown that there is an edematous framework of fibroblasts with abundant interdigitating cytoplasmic processes, a plexus of inflamed blood vessels, and a mixed infiltrate of active inflammatory cells. Solitary cilia were seen to arise from the stromal mesenchymal cells; no mycoplasma or viral inclusions were present. These features may have a relationship to the pathogenesis of nasal polyps. An immunologically induced liberation of vasoactive amines from mast cells results in increased capillary permeability and a consequent excess of intercellular fluid; the stromal cells attempt to check this expansion by an increase in collagen synthesis.

(Arch Otolaryngol 102:589-595, 1976)

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