• Ultrastructural examination of the stroma of simple nasal polyps has shown that there is an edematous framework of fibroblasts with abundant interdigitating cytoplasmic processes, a plexus of inflamed blood vessels, and a mixed infiltrate of active inflammatory cells. Solitary cilia were seen to arise from the stromal mesenchymal cells; no mycoplasma or viral inclusions were present. These features may have a relationship to the pathogenesis of nasal polyps. An immunologically induced liberation of vasoactive amines from mast cells results in increased capillary permeability and a consequent excess of intercellular fluid; the stromal cells attempt to check this expansion by an increase in collagen synthesis.
(Arch Otolaryngol 102:589-595, 1976)
Busuttil A, More IAR, McSeveney D. Ultrastructure of the Stroma of Nasal Polyps: Cilia in Stromal Fibroblasts. Arch Otolaryngol. 1976;102(10):589–595. doi:10.1001/archotol.1976.00780150057002
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: