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October 1976

Lymphocyte Response in Patients With Head and Neck Cancer: Effect of Clinical Stage and Radiotherapy

Author Affiliations

From the departments of radiology (Drs Jenkins, Ray, Perry, and Olson, and Mr Ellis) and otolaryngology (Dr Griffiths), University of Texas Medical Branch at Galveston.

Arch Otolaryngol. 1976;102(10):596-600. doi:10.1001/archotol.1976.00780150064003

• Fifty-three patients with head and neck cancer tested before radiation treatment to determine numbers of blood lymphocytes and immunologic responses to mitogens of lymphocytes in whole-blood cultures had mean values that were 19% to 26% less than values for healthy individuals. Thirty patients whose disease was in stages III or IV had values similar to those in 23 patients whose disease was in stages I or II. Values for 45 patients tested at end of radiotherapy decreased to about 50% of pretreatment values; however, patients with advanced lesions experienced greater decreases (to 24% to 50%) than patients with localized lesions (to 71% to 84%). Patients with advanced lesions usually received radiation to larger areas than patients with localized lesions; therefore, the extent of decline in laboratory values was most likely dependent on volume of tissue treated.

(Arch Otolaryngol 102:596-600, 1976)

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