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March 1977

Histopathologic Changes in the Temporal Bone Resulting From Measles Infection

Author Affiliations

From the Division of Laryngology and Otology, Johns Hopkins University School of Medicine, Baltimore (Dr Bordley); and the Department of Surgery, Division of Otolaryngology and the Department of Audiology and Speech Studies, Michigan State University, East Lansing (Dr Kapur).

Arch Otolaryngol. 1977;103(3):162-168. doi:10.1001/archotol.1977.00780200088010

• We report the pathologic changes in the temporal bones of four children who died of bronchopneumonia secondary to acute measles infection. All suffered from severe necrotizing otitis media characterized by round cell infiltration. In one case, multilobulated giant cells (Warthin-Finkelday) were found in the middle ear. These cells appear to be similar to those found elsewhere within the body during acute measles infection. Inner ear changes were seen in two cases. Severe loss of nerve fibers and ganglion cells with atrophy of the striae vascularis was present in one case. Adhesions were seen between the Reissner membrane and the tectorial membrane in one case and the Reissner membrane and the inner spiral limbus in a second case. Such findings are characteristic of those seen in the cochlear duct of persons suffering from prenatal rubella.

(Arch Otolaryngol 103:162-168, 1977)

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