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Original Article
September 1977

Effect of Ethacrynic Acid on the Stria Vascularis

Author Affiliations

From the Departments of Otolaryngology (Drs Horn and Gates and Ms Langley) and Anatomy (Dr Horn), University of Texas Health Science Center, San Antonio. Dr Horn is now with the Department of Otolaryngology, University of California, San Francisco.

Arch Otolaryngol. 1977;103(9):539-541. doi:10.1001/archotol.1977.00780260069008
Abstract

• The stria vascularis of young albino guinea pigs was examined by scanning electron microscopy at intervals of 30, 60, and 240 minutes after the intracardiac administration of ethacrynic acid (70 mg/kg). Results from this study showed that the appearance of large intercellular spaces in the intermediate region of the stria vascularis was due to acute separation of these cells rather than atrophy, as described by previous investigators. It was probable that these spaces were due to an accumulation of extracellular fluid. In some marginal cells, extrusions of cytoplasm into the endolymphatic space were noted in the 240-minute group of animals. The importance of these extrusions is not apparent at this time.

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