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September 1977

Laryngeal Carcinoma Associated With Multiple Additional Primary TumorsImmunologic Studies

Author Affiliations

From the Departments of Otolaryngology (Drs Goldsher and Eliachar) and Oncology (Dr Bartal and Robinson), Rambam Medical Center and Technion Medical School, Haifa, Isreal.

Arch Otolaryngol. 1977;103(9):550-552. doi:10.1001/archotol.1977.00780260080012

• Four malignant tumors and one benign in a 76-year-old man appeared. Three of the neoplasms were in the respiratory system, and one was a bladder carcinoma; all were linked to heavy smoking habits. The patient underwent immunologic investigations consisting of in vivo testing for cutaneous reactivity, in vitro lymphocyte blastogenesis studies, Tand B-cell level studies, and serum immunoglobulin level studies. The studies have demonstrated anergy to recall antigens, decreased lymphocyte responses to phytohemagglutinin, and low levels of peripheral T-lymphocytes. The serum immunoglobulins were at the upper limit of the normal. The relationship between the patient's immunologic status and the occurrence of multiple primary neoplasms is discussed.

(Arch Otolaryngol 103:550-552, 1977)