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February 1978

Radiation Effects on Microvascular Anastomosis

Author Affiliations

From the Department of Otolaryngology and Maxillofacial Surgery, University of Iowa, Iowa City. Dr Baker is now with the Department of Otorhinolaryngology, University of Michigan, Ann Arbor.

Arch Otolaryngol. 1978;104(2):103-107. doi:10.1001/archotol.1978.00790020045010

• Three groups of rats were studied. Group 1 rats received 6,000 R of irradiation, group 2 rats received 4,000 R, and group 3 rats acted as a control. Four weeks following irradiation, the femoral artery of each rat was cut and reapproximated using microvascular surgical techniques. Four weeks after surgery, the same femoral artery was evaluated for patency. There was no notable effect of irradiation on the patency of subsequently performed anastomosis of these small (1 mm in diameter) muscular arteries. Radiation effects were obvious on histological examination, but the anatomical and physiological alterations apparently were not severe enough to cause early thrombosis after microsurgical manipulation of these vessels.

(Arch Otolaryngol 104:103-107, 1978)

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