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May 1980

Effect of Fluoride on α-Chymotrypsin

Author Affiliations

From the Department of Otolaryngology, All-India Institute of Medical Sciences, Ansari Nagar C 11-10, New Delhi 16, India (Dr Kacker), and Northwestern University Medical School, Chicago (Dr Shambaugh).

Arch Otolaryngol. 1980;106(5):260-261. doi:10.1001/archotol.1980.00790290012005

• Sodium fluoride has been demonstrated by spectrophotometric experiment to have an inhibitory effect on the hydrolyzing action of α-chymotrypsin. Sodium fluoride in moderate therapeutic dosage possibly can retard or completely inhibit the activity of bone-resorbing enzymes in the otospongiotic focus, thus retarding or arresting active expansion of a focus and resulting in stabilizing or arresting the progression of sensorineural hearing loss that is associated with otospongiosis.

(Arch Otolaryngol 106:260-261, 1980)

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