• The empty-sella syndrome consists of the abnormal extension into the sella turcica of an arachnoid diverticulum filled with CSF, which displaces and compresses the pituitary gland. Such a diverticulum can erode through the sellar floor and lead to CSF rhinorrhea through the sphenoidal sinus. Empty-sella syndrome should be considered a diagnostic possibility in patients with nontraumatic CSF rhinorrhea. Diagnosis and treatment are best accomplished with a team approach involving the otolaryngologist, neurosurgeon, neuroradiologist, and neuroendocrinologist. Definitive diagnosis requires pneumoencephalography and thin-section polytomography. Attention should be directed to the possibility of a coexisting pituitary adenoma. Treatment can be accomplished by a transseptal, transsphenoidal approach with localization and repair of the leak.
(Arch Otolaryngol 106:302-305, 1980)
Gray WC, Salcman M, Rao K, Leveque H. CSF Rhinorrhea Associated With the Empty-Sella Syndrome. Arch Otolaryngol. 1980;106(5):302–305. doi:10.1001/archotol.1980.00790290054017
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