• The mean number of lymphocytes, response to phytohemagglutinin (PHA), and response to concanavalin A (Con A) in whole-blood cultures for 106 patients with head and neck cancer were 83%, 73%, and 64%, respectively, of values for healthy control individuals. During radiotherapy, lymphocyte counts declined to 44% and PHA and Con A responses declined to about one third of control values. Lymphocyte counts slowly increased after treatment to 77% of control values after two years, but responses to mitogens remained at about 40%. Responses to PHA and Con A for 38 patients who lived beyond 18 months were significantly greater before and after treatment than responses for 39 patients who died within 18 months. In general, a poor pretreatment response to PHA and Con A correlated with a poor clinical course, whereas responses near the control level indicated a good clinical course.
(Arch Otolaryngol 106:414-418, 1980)
Jenkins VK, Griffiths CM, Ray P, Perry RR, Olson MH. Radiotherapy and Head and Neck Cancer: Role of Lymphocyte Response and Clinical Stage. Arch Otolaryngol. 1980;106(7):414–418. doi:10.1001/archotol.1980.00790310038009
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