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November 1980

The 85th Frontier

Author Affiliations

From the Department of Radiation Oncology, The Johns Hopkins Medical Institutions, Baltimore.

Arch Otolaryngol. 1980;106(11):719-722. doi:10.1001/archotol.1980.00790350061015

• Eighty-five years ago, radiation therapy was discovered, with the restriction of treatment being skin tolerance. This led to time-dose graphs quantitating cure or necrosis. The advent of supervoltage radiation, with skin sparing, treatment simulation and planning, immobilization devices, focus blocks, and computerized tomographic scans, ushered in the era of precision treatment. Radiobiology introduced the hypoxic core and radiation sensitizers. New data concerning the biologic principles of fractional dose, total dose, homogeneity, low-dose implantation, and integration of radiation with surgery, as well as recent protocols, indicate new opportunities for increased local control, cure, and improvement in quality of life.

(Arch Otolaryngol 106:719-722, 1980)