• This study investigated the effects of enbucrilate (Histoacryl) on the middle ear. Small amounts of the adhesive were used in 81 middle-ear operations performed on 50 rabbits. Light microscopic investigation of these ears 1, 2, and 3 months after surgery showed bone necrosis and a granulation tissue reaction surrounded by foreign-body giant cells. Inner-ear changes were observed in a third of the cases. Therefore, enbucrilate should only be used with extreme care and in minute quantities and never near the labyrinthine capsule.
(Arch Otolaryngol 106:734-736, 1980)
Heumann H, Steinbach E. The Effects of an Adhesive in the Middle Ear. Arch Otolaryngol. 1980;106(12):734–736. doi:10.1001/archotol.1980.00790360012004
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