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March 1981

Inhibition of Experimental Esophageal Lye Strictures by Penicillamine

Author Affiliations

From the Department of Head and Neck Surgery, Claude-Bernard Hospital, Paris.

Arch Otolaryngol. 1981;107(3):145-147. doi:10.1001/archotol.1981.00790390011004

• We describe a new experimental model for the study of caustic stenosis of the esophagus in the rat. Sixty-five Wistar rats were given a standard esophageal lye burn. Animals were divided into two groups: (1) a control group and (2) a treatment group that received penicillamine from the day after the esophageal lye burn. Stenosis developed in only two of the 23 treated rats. Our conclusion is that penicillamine-induced lathyrism inhibits the onset of stenosis in the rat. Double-blind controlled studies of the effect of penicillamine in the prevention of corrosive strictures of the esophagus in man seem warranted.

(Arch Otolaryngol 1981;107:145-147)

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