• A two-step ablation technique under visual control was used to clarify the possible sites of origin of the binaural interaction component (BIC) of the auditory brainstem-evoked response (ABR). The BIC is obtained by summing ABRs elicited by monaural clicks to each ear and subtracting this sum from the ABR elicited by binaural clicks. Among the results were the following: first, the ABR and the BIC remained virtually unchanged after collicular aspiration; second, after midsagittal section of the brainstem, both wave III in the ABR and the BIC were abolished. These results suggest that although the inferior colliculus is a powerful integrative center for the processing of binaural signals, the neural structures in the guinea pig necessary for the primary generation of the BIC must be located caudal to the colliculus, yet rostral to the medial nucleus of the trapezoid body.
(Arch Otolaryngol 1981;107:164-168)
John N. Gardi, Charles I. Berlin. Binaural Interaction ComponentsTheir Possible Origins in Guinea Pig Auditory Brainstem Response. Arch Otolaryngol. 1981;107(3):164–168. doi:10.1001/archotol.1981.00790390030009