• Locally advanced (stage III and IV) squamous cell carcinomas of the head and neck are not well controlled with surgery and/or radiotherapy. Trials of chemotherapy before therapy is given for local disease are currently being conducted in an attempt to improve survival and cure rates. Initial studies are preliminary but suggest (1) possible benefit and (2) no excessive toxic effects after surgery and/or radiotherapy. Head and neck surgeons should be aware of the status of these studies.
(Arch Otolaryngol 1981;107:297-299)
Oster MW. Chemotherapy Before Radiotherapy and/or Surgery for Locally Advanced Squamous Cell Carcinomas of the Head and Neck. Arch Otolaryngol. 1981;107(5):297–299. doi:10.1001/archotol.1981.00790410035009
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