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June 1981

Phenytoin-Induced Lymphadenopathy Appearing as a Nasopharyngeal Malignant Neoplasm

Author Affiliations

From the Department of Otolaryngology, University of Washington School of Medicine, Seattle.

Arch Otolaryngol. 1981;107(6):382-384. doi:10.1001/archotol.1981.00790420056012

• A case of phenytoin sodium-induced lymphadenopathy appeared as a nasopharyngeal malignant neoplasm with regional metastases. Cervical lymphadenopathy is a lesser-known drug reaction that is produced by anticonvulsant therapy; under some circumstances, this condition may be confused with head and neck malignant neoplasms. To date, phenytoin-induced nasopharyngeal lymphadenopathy has not previously been reported in the literature. A review of the medical literature provides some interesting facts about the syndrome. A familiarity with this potential complication of anticonvulsant therapy may expedite early diagnosis and appropriate patient treatment.

(Arch Otolaryngol 1981;107:382-384)

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