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February 1982

Histopathological Findings in Clinical Gentamicin Ototoxicity

Author Affiliations

From the Temporal Bone Histopathology Laboratory, University of Toronto (Drs Keene, Hawke, and Farkashidy), and Department of Otolaryngology, Sunnybrook Medical Centre (Dr Barber), Toronto.

Arch Otolaryngol. 1982;108(2):65-70. doi:10.1001/archotol.1982.00790500001001

• The temporal bone histopathological findings in a case of gentamicin sulfateinduced hearing loss and vertigo in an anephric patient undergoing hemodialysis are presented. A study of the sensory neuroepithelium of the cristae and maculae disclosed the presence of vacuoles with clubbing of the sensory cells. In the cochlea, loss of the innermost row of outer hair cells in the basal turn was the most prominent feature. These findings are discussed in light of reports of similar morphological changes in laboratory studies of gentamicin ototoxicity.

(Arch Otolaryngol 1982;108:65-70)

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