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April 1982

Intra-arterial Cisplatin Treatment of Adenoid Cystic Carcinoma

Author Affiliations

From the Departments of Otolaryngology (Drs Sessions and Smith), Pharmacology and Medicine (Dr Lehane), and Radiology (Dr Bryan), Baylor College of Medicine, Houston; and the Department of Otolaryngology and Maxillofacial Surgery, University of Arkansas for Medical Sciences, Little Rock (Dr Suen).

Arch Otolaryngol. 1982;108(4):221-224. doi:10.1001/archotol.1982.00790520021007

• Adenoid cystic carcinoma (ACC) is unique among salivary gland tumors in both its natural history and in its response to nonsurgical treatment methods (ie, radiation and chemotherapy). The chemotherapeutic agent, cisplatin, seems to be unique in its ability to affect ACC. It might be that ACCs of the minor salivary glands are especially vulnerable to the intra-arterial method of administering this drug, because there are accessible feeding vessels to most locations in which these tumors occur. We have treated four patients with advanced ACC with intra-arterial cisplatin. The responses suggest that this method may be a useful adjunct in the management of this tumor both as a preoperative and as a palliative measure.

(Arch Otolaryngol 1982;108:221-224)