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June 1982

Granulocytic Sarcoma (Chloroma) Initially Seen as Acute Mastoiditis

Author Affiliations

From the Departments of OtolaryngologyHead and Neck Surgery (Dr Thompson), Pathology (Dr Ross), and Hematology and Oncology (Dr Reid), Naval Regional Medical Center, Portsmouth, Va. Dr Ross is now with DePaul Hospital, Norfolk, Va.

Arch Otolaryngol. 1982;108(6):388-391. doi:10.1001/archotol.1982.00790540060018

• Granulocytic sarcoma (chloroma) is a localized tumefaction of immature granulocytes that is typically seen in association with myelogenous leukemia. The primitive cell population seen in biopsy material may be misinterpreted as histiocytic lymphoma or other sarcoma unless additional studies are performed. We saw a 36-year-old woman with promyelocytic leukemia in remission who had the signs and symptoms of an acute coalescent mastoiditis. Histologic examination of the surgical specimen, however, demonstrated a granulocytic sarcoma. Our case exemplifies some of the difficulties that may be encountered in the diagnosis of granulocytic sarcoma and illustrates the point that symptoms of an inflammatory process in a patient with a diagnosis of leukemia must be regarded with a degree of suspicion.

(Arch Otolaryngol 1982;108:388-391)

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