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In Reply—The question of the ototoxic effect of the detergent alone, contained in povidone-iodine, was raised at the fourth midwinter meeting of the Association for Research in Otolaryngology in a preliminary presentation of our data. We replied that we were unable to obtain from the manufacturer any statement of content other than the active ingredient.
Generally speaking, cationic detergents are more ototoxic than ionic detergents. However, this is not always the case. For instance, our preliminary data show that the ototoxicity of chlorhexidine is greatly enhanced in the presence of a nonionic detergent (TERIC N9) as well as a cationic detergent (cetrimonium bromide), but not in the presence of another nonionic detergent (F68). Further studies regarding the ototoxicity of detergents alone are being conducted in our laboratory.
We wish to clarify that a major motivation for our study was to examine the effect of two most commonly used povidone-iodine preparations
MORIZONO T, SIKORA MA. Ototoxicity of Detergents-Reply. Arch Otolaryngol. 1982;108(12):808. doi:10.1001/archotol.1982.00790600052014
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