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February 1983

Ultrastructure of Monomorphic Adenoma (Ductal Type) of the Minor Salivary Glands

Author Affiliations

From the Departments of Pathobiology and Oral Pathology (Drs Chaudhry and SunderRaj) and Pathology (Dr Labay), New York University Dental Center; the Department of Oral Diagnosis, School of Dentistry, University of Connecticut, Farmington (Dr Cutler); the Department of Pathology, School of Medicine, State University of New York at Buffalo (Dr Satchidanand); and the New York Eye and Ear Infirmary (Dr Labay).

Arch Otolaryngol. 1983;109(2):118-122. doi:10.1001/archotol.1983.00800160052013

• A monomorphic adenoma (ductal type) of the palatal minor salivary glands is reported. Ultrastructurally, the predominant tumor cells contained zymogenlike dense secretory granules. There was a continuum from tumor cells with little or no secretory granules to ones with increasing numbers of granules. Except for that, the tumor cells shared many of their fine structural features. Histogenetically, the tumor originated from neoplastic proliferations of "undifferentiated" stem cells corresponding to "end-bud" stage of salivary glands embryogenesis. Under neoplastic influences, such cells underwent further cytodifferentiation and functional maturation along the secretory cell lines. In mature salivary glands, such pluripotential cells reside as "reserve" cells in the intercalated ducts.

(Arch Otolaryngol 1983;109:118-122)

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