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February 1983

Etiology of Cleft Lip and Cleft Palate, vol 46, Progress in Clinical and Biological Research

Arch Otolaryngol. 1983;109(2):131. doi:10.1001/archotol.1983.00800160065021

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This volume contains the proceedings of a workshop held at Aislie House, Virginia, which was sponsored by the National Institute of Dental Research and the Society of Craniofacial Genetics. The contributors brought expertise from many diverse disciplines, including animal and human genetics, immunogenetics, biochemistry, developmental biology, mathematical and population genetics, statistics, epidemiology, and clinical practice. As stated in the preface, their charge was to review the state of our knowledge regarding the etiology of facial clefting, point out the deficiencies, and suggest new research directions.

The authors examine all possible environmental and genetic causes of cleft lip and cleft palate. Contributors discuss such topics as animal models for clefting, population studies of incidence and distribution of cleft lip and palate, mathematical models of human clefts, and genetic and phenotypic markers of clefting. In addition to formal papers, the book is distinguished by the unusual general discussions and critiques that follow

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