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May 1983

Interferons and Bronchogenic Carcinoma in Juvenile Laryngeal Papillomatosis

Author Affiliations

From the Center for Pediatric Oncology SE Netherlands, the Department of Pediatrics (Dr Schouten), the Department of Otorhinolaryngology (Drs van den Broek and Cremers), the Division of Lung Diseases, Department of Internal Medicine (Dr Jongerius), and the Department of Pathology (Drs Meyer and Vooys), St Radboud Hospital, Catholic University, Nijmegen, the Netherlands.

Arch Otolaryngol. 1983;109(5):289-291. doi:10.1001/archotol.1983.00800190011003

• A squamous cell carcinoma of the bronchus developed in a patient during the course of juvenile laryngeal papillomatosis. This patient had received interferon treatment, which caused regression of the papillomas, but apparently had no influence on the progression of the bronchogenic squamous cell carcinoma. This suggests that interferons have an antiviral effect, but not an antitumor effect in the dosage used. No radiation therapy had been given in the past and no other carcinogenic factors are obvious. However, human papilloma viruses, which cause juvenile laryngeal papillomatosis, have been incriminated in the genesis of squamous cell carcinomas.

(Arch Otolaryngol 1983;109:289-291)

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