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November 1983

Single Agent Chemotherapy for Head and Neck Cancers: The Murine Subrenal Capsule Assay

Author Affiliations

From the Division of Head and Neck Surgical Oncology, Department of Otolaryngology—Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City.

Arch Otolaryngol. 1983;109(11):715-718. doi:10.1001/archotol.1983.00800250009002

• The murine subrenal capsule assay was used to determine chemotherapeutic sensitivities of metastatic, primary, or recurrent head and neck cancers. Tumor fragments (1 cu mm) were implanted under the renal capsule of 2- to 4-month-old normal female C57 BL/6 X DBA/2 F, hybrid mice. Xenografts included 20 squamous cell carcinomas (SCCs), one mucoepidermoid carcinoma, one adenoid cystic carcinoma, and two melanomas. Groups of tumor-bearing mice were treated with chemotherapy daily for five days. Sensitivities of the tumor were assessed on day 6 by comparison of final implant size with initial implant size. Significant oncolytic activity was detected against 16 of 24 tumors (14 of 20 SCCs and both melanomas). Correlations between the in vivo assay and clinical studies are needed to determine its predictive value.

(Arch Otolaryngol 1983;109:715-718)

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