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December 1983

A Nontoxic Adjuvant Treatment for Advanced Head and Neck Cancer

Author Affiliations

From the Oncology Section, Buffalo Veterans Administration Medical Center (Dr Spaulding); the Departments of Medicine (Dr Spaulding), Otolaryngology (Drs Spaulding, Khan, and Loré and Ms Sundquist), Medical Oncology (Dr Vasquez), and Head and Neck Surgery (Drs Khan and Loré), State University of New York at Buffalo; and the Department of Medical Oncology, Roswell Park Memorial Institute, Buffalo (Dr Vasquez).

Arch Otolaryngol. 1983;109(12):789-791. doi:10.1001/archotol.1983.00800260011003

• A variety of adjuvant chemotherapy programs have been described for advanced head and neck cancer. The protocol described herein is nontoxic and particularly appropriate for patients with advanced tumors who cannot, because of severe pulmonary disease, tolerate bleomycin sulfate. Eighty percent of patients treated with this combination responded with more than 50% tumor shrinkage. Chemotherapy was followed by either surgery, radiation therapy, or both. Long-term control with this combined modality therapy was better in oral cavity and oropharyngeal lesions than in tumors from the hypopharynx.

(Arch Otolaryngol 1983;109:789-791)

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