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July 1984

Oral Desensitization to Penicillin in Necrotizing (Malignant) External Otitis

Author Affiliations

From the Otologic Medical Group, Inc, Los Angeles. Dr Thedinger is now with the University of Kansas Medical Center, Kansas City.

Arch Otolaryngol. 1984;110(7):474-476. doi:10.1001/archotol.1984.00800330056012

• Penicillin allergy can complicate the treatment of life-threatening infections. When a βlactam (penicillin) drug is the treatment of choice, true allergy can be safely overcome by a recent, oral method of desensitization to penicillin. Patients with positive skin test results can be desensitized within four hours with oral, subcutaneous, and then intramuscular administration of progressively increased doses of penicillin G. We used this method successfully in a patient with severe necrotizing (malignant) external otitis.

(Arch Otolaryngol 1984;110:474-476)

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