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Article
November 1984

Olfactory Neuroblastoma: Chemotherapy and Radiotherapy for Extensive Disease

Author Affiliations

From the Sections of Hematology and Oncology (Dr Weiden), Otolaryngology, Plastic and Reconstructive Surgery (Dr Yarington), and Radiation Oncology (Dr Richardson), Mason Clinic, Seattle.

Arch Otolaryngol. 1984;110(11):759-760. doi:10.1001/archotol.1984.00800370061016
Abstract

• A patient with olfactory neuroblastoma had extensive involvement of the nasopharynx, sinuses and orbit, and cervical metastasis. After surgical biopsy and excision of metastatic disease, she was treated with chemotherapy: three cycles of high-dose cisplatin (100 mg/sq m) and infusion of fluorouracil (1 g/sq m/day for five days). Subsequent treatment included definitive radiation therapy followed by three additional cycles of chemotherapy. The patient is free of disease three years after initiating therapy. This case report demonstrates the potential efficacy of planned combined modality therapy, including early chemotherapy in the control of locally advanced, unresectable olfactory neuroblastoma.

(Arch Otolaryngol 1984;110:759-760)

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