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November 1984

RAST in Clinical Allergy

Arch Otolaryngol. 1984;110(11):770. doi:10.1001/archotol.1984.00800370072022

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This text incorporates selected topics presented at two postgraduate seminars on the use of the radioallergosorbent test (RAST) in the diagnosis and treatment of the allergic patient. The seminars were sponsored by and the text edited by Fadal and Nalebuff. The foreword by Bellanti describes the RAST as a reliable correlate of allergic disease history, mucosal provocation, and skin testing.

Early workers with IgE are among the notable speakers contributing to the seminars. Johansson outlines the research at the Karolinska Institute in Stockholm, leading to the discovery of IgE. The specific characteristics of this immunoglobulin with its propensity to initiate mediator release as determined at Johns Hopkins is described by Ishizaka.

The text offers a fair appraisal of the advantages and disadvantages of the RAST. It stresses the greater precision offered over the skin whealing response for quantitation of patient sensitivity to specific antigens. The authors emphasize the decrease in

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