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December 1984

Electronystagmographic Findings in Long-term Low-Dose Quinine Ingestion: A Preliminary Report

Author Affiliations

From the Otolaryngology—Head and Neck Surgery Section (Drs Zajtchuk and Mihail), the Audiology and Speech Center (Ms Chadwick), Department of Surgery, Walter Reed Army Medical Center, and the Divisions of Toxicology (MAJ Jewell) and Aerospace Medicine (Dr Dunne), Armed Forces Institute of Pathology, Washington, DC.

Arch Otolaryngol. 1984;110(12):788-791. doi:10.1001/archotol.1984.00800380018006

• Seventeen subjects were used in this study to measure the long-term effects of low-dose quinine ingestion as correlated with electronystagmographic (ENG) findings in humans. Four subjects served as controls, nine subjects (low-dose group) drank 52.5 mg of quinine per day, and four subjects (high-dose group) drank 105 mg of quinine per day in commercially prepared tonic water. Only the high-dose group showed transient positional testing abnormalities on ENG. In our experiment, the high-dose group ingested one third of the recommended Food and Drug Administration adult daily oral dose of quinine.

(Arch Otolaryngol 1984;110:788-791)

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