• Seventeen subjects were used in this study to measure the long-term effects of low-dose quinine ingestion as correlated with electronystagmographic (ENG) findings in humans. Four subjects served as controls, nine subjects (low-dose group) drank 52.5 mg of quinine per day, and four subjects (high-dose group) drank 105 mg of quinine per day in commercially prepared tonic water. Only the high-dose group showed transient positional testing abnormalities on ENG. In our experiment, the high-dose group ingested one third of the recommended Food and Drug Administration adult daily oral dose of quinine.
(Arch Otolaryngol 1984;110:788-791)
Zajtchuk JT, Mihail R, Jewell JS, Dunne MJ, Chadwick SG. Electronystagmographic Findings in Long-term Low-Dose Quinine Ingestion: A Preliminary Report. Arch Otolaryngol. 1984;110(12):788–791. doi:10.1001/archotol.1984.00800380018006
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